Source localization approach for functional DOT using MUSIC and FDR control.

In this paper, we formulate diffuse optical tomography (DOT) problems as a source localization problem and propose a MUltiple SIgnal Classification (MUSIC) algorithm for functional brain imaging application. By providing MUSIC spectra for major chromophores such as oxy-hemoglobin (HbO) and deoxy-hemoglobin (HbR), we are able to investigate the spatial distribution of brain activities. Moreover, the false discovery rate (FDR) algorithm can be applied to control the family-wise error in the MUSIC spectra. The minimum distance between the center of mass in DOT and the Montreal Neurological Institute (MNI) coordinates of target regions in experiments was between approximately 6 and 18 mm, and the displacement of the center of mass in DOT and fMRI ranged between 12 and 28 mm, which demonstrate the legitimacy of the DOT-based imaging. The proposed brain mapping method revealed its potential as an alternative algorithm to monitor the brain activation.